Synthesis, Characterization and Anticancer Activity of Some Benzothiazole and Thiazole Derivatives

Hassan, Aisha Y.; Sarg, Marwa; Husseiny, Ebtehal

doi:10.21608/aprh.2020.27931.1104

Synthesis, Characterization and Anticancer Activity of Some Benzothiazole and Thiazole Derivatives

Document Type : Research Article

Authors

¹ Department of Chemistry, Faculty of Science(Girls), Al-Azhar University, Nasr City, Cairo, Egypt.

² Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.

10.21608/aprh.2020.27931.1104

Abstract

Objective: This study aimed synthesis of benzothiazole and thiazole derivatives due to the importance of these heterocycles as anticancer. Method: Novel benzothiazole and thiazole derivatives 2-40 were synthesized through different chemical reactions. Results: Structures of these compounds were confirmed by spectral and elemental analyses. The obtained compounds were evaluated for their in vitro antitumor activity against 60 human cancer cell lines by the National Cancer Institute (NCI). Conclusion: Twelve compounds 4, 6, 10, 12, 13, 16, 18, 20, 21, 25, 28b and 40 wereselected by NCI for evaluation and have anticancer activity.

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