Helali, A., Sarg, M., Elzoghbi, M. (2021). Utility of Activated Nitriles in the Synthesis of some New Pyridine and Fused Pyridine Derivatives with Anticancer Activity. Journal of Advanced Pharmacy Research, 5(1), 180-201. doi: 10.21608/aprh.2020.37889.1114
Aisha Helali; Marwa Sarg; Mona Elzoghbi. "Utility of Activated Nitriles in the Synthesis of some New Pyridine and Fused Pyridine Derivatives with Anticancer Activity". Journal of Advanced Pharmacy Research, 5, 1, 2021, 180-201. doi: 10.21608/aprh.2020.37889.1114
Helali, A., Sarg, M., Elzoghbi, M. (2021). 'Utility of Activated Nitriles in the Synthesis of some New Pyridine and Fused Pyridine Derivatives with Anticancer Activity', Journal of Advanced Pharmacy Research, 5(1), pp. 180-201. doi: 10.21608/aprh.2020.37889.1114
Helali, A., Sarg, M., Elzoghbi, M. Utility of Activated Nitriles in the Synthesis of some New Pyridine and Fused Pyridine Derivatives with Anticancer Activity. Journal of Advanced Pharmacy Research, 2021; 5(1): 180-201. doi: 10.21608/aprh.2020.37889.1114
Utility of Activated Nitriles in the Synthesis of some New Pyridine and Fused Pyridine Derivatives with Anticancer Activity
3Pharmaceutical Chemistry Department, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt.
Abstract
Objective: This study aimed synthesis of pyridine and fused pyridine derivatives based on the importance of these heterocycles as anticancer. Method: Novel pyridine and fused pyridine derivatives 3-35 were synthesized through different chemical reactions. Results: Structures of these compounds were confirmed by spectral and elemental analyses. The obtained compounds were evaluated for their in vitro antitumor activity against liver HepG2 and breast MCF-7 cancer cell lines compared to the reference drug (5-fluorouracil). Conclusion: Compounds 4, 12, 13, 19, 21, 28 and 29 were found to be the most active against both cell lines exhibiting IC50 values ranging from 3.05-11.50 μg/mL and 2.87-6.23 μg/mL against HepG-2 and MCF-7 cell lines; respectively
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