El-Shanbaky, H., Abd El-Hameed, R., Mohamed, M. (2021). Synthesis of Heterocyclic and Non-heterocyclic Compounds Derived from Novel 2-Furanones and Evaluation of their Anti-viral Activity. Journal of Advanced Pharmacy Research, 5(1), 202-210. doi: 10.21608/aprh.2020.49788.1120
Hend Medhat El-Shanbaky; Rania Abd El-Hameed; Mosad Sayed Mohamed. "Synthesis of Heterocyclic and Non-heterocyclic Compounds Derived from Novel 2-Furanones and Evaluation of their Anti-viral Activity". Journal of Advanced Pharmacy Research, 5, 1, 2021, 202-210. doi: 10.21608/aprh.2020.49788.1120
El-Shanbaky, H., Abd El-Hameed, R., Mohamed, M. (2021). 'Synthesis of Heterocyclic and Non-heterocyclic Compounds Derived from Novel 2-Furanones and Evaluation of their Anti-viral Activity', Journal of Advanced Pharmacy Research, 5(1), pp. 202-210. doi: 10.21608/aprh.2020.49788.1120
El-Shanbaky, H., Abd El-Hameed, R., Mohamed, M. Synthesis of Heterocyclic and Non-heterocyclic Compounds Derived from Novel 2-Furanones and Evaluation of their Anti-viral Activity. Journal of Advanced Pharmacy Research, 2021; 5(1): 202-210. doi: 10.21608/aprh.2020.49788.1120
Synthesis of Heterocyclic and Non-heterocyclic Compounds Derived from Novel 2-Furanones and Evaluation of their Anti-viral Activity
Objective: The aim of the present study is to synthesize novel 2-furanones due to their biological activities and also their ability to be converted to several biologically active heterocyclic and non-heterocyclic compounds. Methods: Two novel 2-furanone derivatives were synthesized and used to prepare fourteen heterocyclic and non-heterocyclic compounds. Structures of all the newly synthesized compounds were confirmed by elemental and spectral analysis including Mass, IR and 1H-NMR spectroscopy. Evaluation of antiviral activity of selected examples of the obtained compounds was performed using two gastroenteric viruses: adenovirus and rotavirus. Results: Two pyridazinone derivatives namely; 3-(3,4-Dichlorophenyl)-5-[(2-methoxypheny)l-methyl]-1H-pyridazin-6-one (7a) and 3-(3,4-Dichlorophenyl)-5-[(4-fluropheny)l-methyl]-1H-pyridazin-6-one (7b) showed high activities against rotavirus. Conclusions: Compounds 7a and 7b can be considered as promising anti-rotaviral agents needing further investigations and clinical studies.
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