Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives

Elgiushy, Hossam; Hammad, Sherif; Hassan, Ashraf Sayed; Aboutaleb, Nageh; Abouzid, Khaled

doi:10.21608/aprh.2018.2839.1049

Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives

Document Type : Review Article

Authors

¹ Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan 11795, Cairo, Egypt.

² Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt

³ Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University,Abbassia 11566 Cairo , Egypt

10.21608/aprh.2018.2839.1049

Abstract

Acrylamide moiety is a pronounced Michael acceptor that has drawn much interest in a wide array of drugs designed for various therapeutic purposes. Herein we outline different synthetic pathways, scientific bases for its chemical reactivity and how it is functionalized for design of new therapeutic entities, in addition to a brief insight into spectrum of reported biological activities of acrylamide containing compounds up to date.

Keywords