Elgiushy, H., Hammad, S., Hassan, A., Aboutaleb, N., Abouzid, K. (2018). Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives. Journal of Advanced Pharmacy Research, 2(4), 221-237. doi: 10.21608/aprh.2018.2839.1049
Hossam Elgiushy; Sherif Hammad; Ashraf Sayed Hassan; Nageh Aboutaleb; khaled Abouzid. "Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives". Journal of Advanced Pharmacy Research, 2, 4, 2018, 221-237. doi: 10.21608/aprh.2018.2839.1049
Elgiushy, H., Hammad, S., Hassan, A., Aboutaleb, N., Abouzid, K. (2018). 'Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives', Journal of Advanced Pharmacy Research, 2(4), pp. 221-237. doi: 10.21608/aprh.2018.2839.1049
Elgiushy, H., Hammad, S., Hassan, A., Aboutaleb, N., Abouzid, K. Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives. Journal of Advanced Pharmacy Research, 2018; 2(4): 221-237. doi: 10.21608/aprh.2018.2839.1049
Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives
1Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan 11795, Cairo, Egypt.
2Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt
3Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University,Abbassia 11566 Cairo , Egypt
Abstract
Acrylamide moiety is a pronounced Michael acceptor that has drawn much interest in a wide array of drugs designed for various therapeutic purposes. Herein we outline different synthetic pathways, scientific bases for its chemical reactivity and how it is functionalized for design of new therapeutic entities, in addition to a brief insight into spectrum of reported biological activities of acrylamide containing compounds up to date.
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