Ismail, N. (2022). Balanites aegyptiaca (Heglig Dates) Reduces Oxidative Stress and Biophysical Alterations of Erythrocyte Membranes in Streptozotocin-Induced Diabetic Rats. Journal of Advanced Pharmacy Research, 6(2), 78-83. doi: 10.21608/aprh.2022.125054.1151
Naglaa Ismail. "Balanites aegyptiaca (Heglig Dates) Reduces Oxidative Stress and Biophysical Alterations of Erythrocyte Membranes in Streptozotocin-Induced Diabetic Rats". Journal of Advanced Pharmacy Research, 6, 2, 2022, 78-83. doi: 10.21608/aprh.2022.125054.1151
Ismail, N. (2022). 'Balanites aegyptiaca (Heglig Dates) Reduces Oxidative Stress and Biophysical Alterations of Erythrocyte Membranes in Streptozotocin-Induced Diabetic Rats', Journal of Advanced Pharmacy Research, 6(2), pp. 78-83. doi: 10.21608/aprh.2022.125054.1151
Ismail, N. Balanites aegyptiaca (Heglig Dates) Reduces Oxidative Stress and Biophysical Alterations of Erythrocyte Membranes in Streptozotocin-Induced Diabetic Rats. Journal of Advanced Pharmacy Research, 2022; 6(2): 78-83. doi: 10.21608/aprh.2022.125054.1151
Balanites aegyptiaca (Heglig Dates) Reduces Oxidative Stress and Biophysical Alterations of Erythrocyte Membranes in Streptozotocin-Induced Diabetic Rats
Physics Department, Biophysics Division, Faculty of Women for Arts, Science and Education, Ain Shams University. Cairo, Egypt.
Abstract
Objectives: In diabetic conditions, hyperglycemia-induced oxidative stress promotes alterations of function and other properties of the erythrocyte membrane. In this study, we investigated the effects of Balanitesaegyptiaca (100 mg/kg) on biophysical characteristics of erythrocyte membranes in streptozotocin-induced diabetic rats. Methods: Twenty-four male rats were divided into three groups as follows: Group 1, control group; Group 2, diabetic group; and Group 3, diabetic plus Balanitesaegyptiaca (Heglig dates). After 30 days of treatment, we determined erythrocyte osmotic fragility, AC conductivity, auto-oxidation rate of hemoglobin, and electron paramagnetic resonance. Results: The osmotic fragility was significantly higher in the diabetic group compared to the control and diabetic with Heglig dates. We also found a significant decrease in the hemoglobin concentration. Conclusion: Four weeks of daily supplementation with 100 mg/kg Heglig dates suggest the beneficial role of Balanitesaegyptiaca fruit as a hypoglycemic and could reduce the levels of oxidative stress markers by inhibiting lipid peroxidation in streptozotocin-induced diabetic rats.
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