Preparation and Characterization of Terbutaline Sulphate-loaded Chitosan/Carbopol Nanoparticles

Abd El-motelb, Soha; Nasereldin, Mohamed; Refai, Hanan

doi:10.21608/aprh.2019.6474.1071

Preparation and Characterization of Terbutaline Sulphate-loaded Chitosan/Carbopol Nanoparticles

Document Type : Short Communication

Authors

¹ College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt.

² Department of Pharmaceutics, Faculty of Pharmacy, Helwan University, Helwan, Egypt.

10.21608/aprh.2019.6474.1071

Abstract

Objective: The objective of the present study is to prepare and evaluate terbutaline sulphate loaded chitosan/carbapol nanoparticles for treatment of asthma via nasal route. Methods: Nanoparticles were prepared by ionic gelation method with various concentrations of chitosan and carbopol. The developed Terbutaline sulphate-loaded chitosan/carbopol nanoparticles were analysed for particle size, dispersion homogeneity, zeta potential, entrapment efficiency, in vitro drug release and fourier transform infrared ray spectroscopy (FT-IR). Results: The sizes of all of the formulations which showed opalescent colloidal dispersions visually were in nanorange which was between 575.31 nm and 601.12 nm and entrapment efficiency ranged from 34.71 % to 40.04 % and zeta potential from -27.04 mV to -33.62 mV. All the CS/CP nanodispersions showed an initial burst release followed by a more gradual sustained release. The FT-IR studies suggested that an interaction between CS and TS during the formation of nanoparticles. Conclusion: CS/CP nanoparticles were successfully prepared by ionic gelation method and may also be useful for a variety of other therapeutic delivery systems.

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