Hashim, F., Elkhateeb, D., Ali, M., Abdel-Rashid, R. (2022). Effect of Formulation Variables and Bile Salts Addition on Entrapment Efficiency of Curcumin Loaded Niosomes. Journal of Advanced Pharmacy Research, 6(3), 123-132. doi: 10.21608/aprh.2022.133710.1172
Fahima Hashim; Dalia Elkhateeb; Marwa M. Ali; Rania S. Abdel-Rashid. "Effect of Formulation Variables and Bile Salts Addition on Entrapment Efficiency of Curcumin Loaded Niosomes". Journal of Advanced Pharmacy Research, 6, 3, 2022, 123-132. doi: 10.21608/aprh.2022.133710.1172
Hashim, F., Elkhateeb, D., Ali, M., Abdel-Rashid, R. (2022). 'Effect of Formulation Variables and Bile Salts Addition on Entrapment Efficiency of Curcumin Loaded Niosomes', Journal of Advanced Pharmacy Research, 6(3), pp. 123-132. doi: 10.21608/aprh.2022.133710.1172
Hashim, F., Elkhateeb, D., Ali, M., Abdel-Rashid, R. Effect of Formulation Variables and Bile Salts Addition on Entrapment Efficiency of Curcumin Loaded Niosomes. Journal of Advanced Pharmacy Research, 2022; 6(3): 123-132. doi: 10.21608/aprh.2022.133710.1172
Effect of Formulation Variables and Bile Salts Addition on Entrapment Efficiency of Curcumin Loaded Niosomes
1Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo 11795, Egypt.
2Central Administration of Drug Control, Egyptian Drug Authority, Dokki, Giza, 12655, Egypt.
Abstract
Background: Curcumin is an important natural compound that has been extensively studied for its multifunctional pharmacological activities. Different nanotechnological techniques have been applied for improving its poor solubility and bioavailability. Objectives: This research aimed to study the effect of formulation variables on the entrapment efficiency of curcumin-loaded niosomes (curcusomes) made by a thin-film hydration technique. Methods: Curcumin-loaded noisome were prepared using the thin-film hydration technique using Span 40 and 60 as surfactants, in addition to bile salts and cholesterol. The surfactant and cholesterol were added to curcumin in different ratios, with/without the addition of 10% of bile salts. Results: Eighteen formulae were obtained from the addition of bile salts and spans. Results showed that increased surfactant concentration and low cholesterol ratio enhanced the %EE of formulae. Conclusion: The formulation of curcumin-loaded niosomes with the thin-film hydration method where span 40 or span 60 are used as surfactant enhances the %EE of curcusomes which in turn improves the poor solubility and bioavailability of curcumin. The addition of bile salts enhanced the %EE which will be investigated furtherly for more in vitro and in vivo studies.
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