Pyrimidines as Anticancer and Antiviral: Synthesis & Reactions (A Review)

Document Type : Review Article

Authors

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Cairo,11795, Egypt

Abstract

Background: The interest of many medicinal and organic chemists has been attracted to the synthesis of pyrimidines and their analogues due to their highly biological and medicinal properties. Objectives& Methodology: Based on these activities, this review discusses the various recent methods for the synthesis of these heterocyclic compounds during the period of 2017 to 2021 with certain two main medicinal actions. Conclusion: Pyrimidine moiety bearing compounds, are synthesized, and reacted either through one-pot synthesis or multi-step synthesis pathways, in catalytic and solvent free condition or using catalysts and solvent.

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Journal of Advanced Pharmacy Research
Volume 6, Issue 4
October 2022
Pages 155-180

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