Azzam, A., Khaled, H., Hesham, M. (2022). The Prevalence of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in Egypt: A Systematic Review and Meta-Analysis. Journal of Advanced Pharmacy Research, 6(4), 238-248. doi: 10.21608/aprh.2022.142365.1177
Ahmed Azzam; Heba Khaled; Marwan Hesham. "The Prevalence of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in Egypt: A Systematic Review and Meta-Analysis". Journal of Advanced Pharmacy Research, 6, 4, 2022, 238-248. doi: 10.21608/aprh.2022.142365.1177
Azzam, A., Khaled, H., Hesham, M. (2022). 'The Prevalence of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in Egypt: A Systematic Review and Meta-Analysis', Journal of Advanced Pharmacy Research, 6(4), pp. 238-248. doi: 10.21608/aprh.2022.142365.1177
Azzam, A., Khaled, H., Hesham, M. The Prevalence of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in Egypt: A Systematic Review and Meta-Analysis. Journal of Advanced Pharmacy Research, 2022; 6(4): 238-248. doi: 10.21608/aprh.2022.142365.1177
The Prevalence of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in Egypt: A Systematic Review and Meta-Analysis
1Department of Microbiology and Immunology, Faculty of Pharmacy, Helwan University, Ain Helwan 11795, Cairo, Egypt
2Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
Abstract
Background: Metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa represents a serious hazard to humanity because of its high mortality rate, ability to hydrolyze all beta-lactam antibiotics, including carbapenem, and absence of a clinically approved inhibitor. There are several studies conducted in Egypt that report a heterogeneous incidence of MBL among Pseudomonas aeruginosa clinical isolates. Methods: We performed a systematic search in MEDLINE [PubMed], Scopus, Google scholar, and Web of Science. Out of 1882 records, 20 studies agreed with the inclusion and exclusion criteria and are included in our review. Results: Our investigation revealed a high incidence of MBL-producing Pseudomonas aeruginosa of about 33.7% (95% CI: 19.3-48) and MBL-mediated Imipenem resistance among P. aeruginosa of about 74.1% (95% CI: 63.5-84.6). Furthermore, based on the included studies and other molecular studies conducted in Egypt, among MBL-encoding genes, blaVIM appeared to be the most prevalent MBL gene in clinically isolated Pseudomonas aeruginosa in Egypt. Conclusion: This high disseminating rate raises the alarm to support both antimicrobial stewardship activities and infection control programs to prevent further increases.
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