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El-Olemy, A. (2017). Simultaneous UV Spectrophotometric Determination of Pravastatin Sodium and Pioglitazone Hydrochloride in Pharmaceutical Preparations. Journal of Advanced Pharmacy Research, 1(3), 143-149. doi: 10.21608/aprh.2017.3359
Ahmed El-Olemy. "Simultaneous UV Spectrophotometric Determination of Pravastatin Sodium and Pioglitazone Hydrochloride in Pharmaceutical Preparations". Journal of Advanced Pharmacy Research, 1, 3, 2017, 143-149. doi: 10.21608/aprh.2017.3359
El-Olemy, A. (2017). 'Simultaneous UV Spectrophotometric Determination of Pravastatin Sodium and Pioglitazone Hydrochloride in Pharmaceutical Preparations', Journal of Advanced Pharmacy Research, 1(3), pp. 143-149. doi: 10.21608/aprh.2017.3359
El-Olemy, A. Simultaneous UV Spectrophotometric Determination of Pravastatin Sodium and Pioglitazone Hydrochloride in Pharmaceutical Preparations. Journal of Advanced Pharmacy Research, 2017; 1(3): 143-149. doi: 10.21608/aprh.2017.3359

Simultaneous UV Spectrophotometric Determination of Pravastatin Sodium and Pioglitazone Hydrochloride in Pharmaceutical Preparations

Article 2, Volume 1, Issue 3, July 2017, Page 143-149  XML PDF (618.05 K)
Document Type: Research Article
DOI: 10.21608/aprh.2017.3359
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Author
Ahmed El-Olemy email
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt
Abstract
Objectives: This study aimed to develop simple UV spectrophotometric methods for simultaneous determination of pravastatin sodium and pioglitazone hydrochloride without previous separation. Methods. The first method is the first derivative, where the peak amplitudes of first derivative of absorption spectra were measured at 249.7 and 277 nm for pravastatin sodium and pioglitazone hydrochloride respectively. The second method is the first derivative of the ratio spectra, where the peak amplitudes were measured at 249.6 and 276.6 nm for pravastatin sodium and pioglitazone hydrochloride respectively. Results. The proposed methods were validated according to International Conference on Harmonization (ICH) guidelines and successfully applied for simultaneous determination of both drugs in their combined dosage form. Conclusion. The proposed methods are simple, rapid, economic, accurate and precise to simultaneously determine pravastatin and pioglitazone in pure form and in pharmaceutical dosage form without previous separation steps.
 
Keywords
Pravastatin sodium; Pioglitazone Hydrochloride; First derivative; Ratio derivative
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