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El-Leithy, E., El-Fiky, G., Nabil, M. (2017). Characterization of Degradation Products Resulted from Acidic Hydrolysis of Lisinopril Under Drastic Conditions. Journal of Advanced Pharmacy Research, 1(4), 201-208. doi: 10.21608/aprh.2017.4041
Eman El-Leithy; Gena El-Fiky; Mohamed Nabil. "Characterization of Degradation Products Resulted from Acidic Hydrolysis of Lisinopril Under Drastic Conditions". Journal of Advanced Pharmacy Research, 1, 4, 2017, 201-208. doi: 10.21608/aprh.2017.4041
El-Leithy, E., El-Fiky, G., Nabil, M. (2017). 'Characterization of Degradation Products Resulted from Acidic Hydrolysis of Lisinopril Under Drastic Conditions', Journal of Advanced Pharmacy Research, 1(4), pp. 201-208. doi: 10.21608/aprh.2017.4041
El-Leithy, E., El-Fiky, G., Nabil, M. Characterization of Degradation Products Resulted from Acidic Hydrolysis of Lisinopril Under Drastic Conditions. Journal of Advanced Pharmacy Research, 2017; 1(4): 201-208. doi: 10.21608/aprh.2017.4041

Characterization of Degradation Products Resulted from Acidic Hydrolysis of Lisinopril Under Drastic Conditions

Article 4, Volume 1, Issue 4, October 2017, Page 201-208  XML PDF (913.8 K)
Document Type: Research Article
DOI: 10.21608/aprh.2017.4041
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Authors
Eman El-Leithy1, 2; Gena El-Fiky1, 3; Mohamed Nabil4
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6thof October, Giza, Egypt.
22Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, AinHelwan, Cairo, Egypt
3Pharmaceutical Technology Devision, National Research Center, El-Dokki, Giza, Egypt.
410th of Ramadan for Pharmaceutical and DiagnosticReagents, 6thof October, Giza, Egypt.
Abstract
Four degradation products resulted from acidic hydrolysis of lisinopril under drastic conditions. The degradation products were detected by means of ultra-performance liquid chromatography coupled with mass/mass spectroscopy (LC-MS/MS) with simple and sensitive method suitable for LC-MS/MS analysis. The fragmentation behaviors of lisinopril and degradation products were investigated. Two degradation products were described in E.Ph.(8th) as impurities. Both of 6-amino-2-((1-carboxy-3-phenylpropyl)amino) hexanoic acid  (m/z 309+)and 1-(2,6-diaminohexanoyl)pyrrolidine-2-carboxylic acid (m/z 244+) were formed and identified.
Keywords
Lisinopril analysis; Degradation products; LC-MS/MS; Chemical structure elucidation
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