Characterization of Degradation Products Resulted from Acidic Hydrolysis of Lisinopril Under Drastic Conditions

Document Type : Research Article

Authors

1 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6thof October, Giza, Egypt.

2 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, AinHelwan, Cairo, Egypt

3 Pharmaceutical Technology Devision, National Research Center, El-Dokki, Giza, Egypt.

4 10th of Ramadan for Pharmaceutical and DiagnosticReagents, 6thof October, Giza, Egypt.

Abstract

Four degradation products resulted from acidic hydrolysis of lisinopril under drastic conditions. The degradation products were detected by means of ultra-performance liquid chromatography coupled with mass/mass spectroscopy (LC-MS/MS) with simple and sensitive method suitable for LC-MS/MS analysis. The fragmentation behaviors of lisinopril and degradation products were investigated. Two degradation products were described in E.Ph.(8th) as impurities. Both of 6-amino-2-((1-carboxy-3-phenylpropyl)amino) hexanoic acid  (m/z 309+)and 1-(2,6-diaminohexanoyl)pyrrolidine-2-carboxylic acid (m/z 244+) were formed and identified.

Keywords

Journal of Advanced Pharmacy Research
Volume 1, Issue 4
October 2017
Pages 201-208

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