Ebied, M., Zaghary, W., Amin, K., Hammad, S. (2017). Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted Benzo[h]quinazolines, Benzo[h]quinolines and Naphthaleno[d]thiazoles. Journal of Advanced Pharmacy Research, 1(4), 216-227. doi: 10.21608/aprh.2017.4043
Mohammed Ebied; Wafaa Zaghary; Kamelia Amin; Sherif Hammad. "Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted Benzo[h]quinazolines, Benzo[h]quinolines and Naphthaleno[d]thiazoles". Journal of Advanced Pharmacy Research, 1, 4, 2017, 216-227. doi: 10.21608/aprh.2017.4043
Ebied, M., Zaghary, W., Amin, K., Hammad, S. (2017). 'Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted Benzo[h]quinazolines, Benzo[h]quinolines and Naphthaleno[d]thiazoles', Journal of Advanced Pharmacy Research, 1(4), pp. 216-227. doi: 10.21608/aprh.2017.4043
Ebied, M., Zaghary, W., Amin, K., Hammad, S. Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted Benzo[h]quinazolines, Benzo[h]quinolines and Naphthaleno[d]thiazoles. Journal of Advanced Pharmacy Research, 2017; 1(4): 216-227. doi: 10.21608/aprh.2017.4043
Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted Benzo[h]quinazolines, Benzo[h]quinolines and Naphthaleno[d]thiazoles
1Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo, Egypt.
Abstract
Three series of ring-equivalent tricyclic benzo[h]quinazolines, benzo[h]quinolines and naphthaleno[d]thiazoles analogs were designed as bioisosteres and synthesized. The chemical structures of the synthesized agents were elucidated based on their spectral data and elemental analyses. The antimicrobial activity of some of the synthesized compounds was screened and only2-bromo derivative IX and aminothiazole compound X exhibited broad antimicrobial effectiveness. The antifungal MIC value of Xwas1.85 mg/mL.
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