Adel, M., Serya, R., Lasheen, D., Abouzid, K. (2018). Pyrrolopyrimidine: A Versatile Scaffold for Construction of Targeted Anti-cancer Agents. Journal of Advanced Pharmacy Research, 2(1), 1-19. doi: 10.21608/aprh.2017.4832
Mai Adel; Rabah A. T. Serya; Deena S. Lasheen; Khaled A A. M. Abouzid. "Pyrrolopyrimidine: A Versatile Scaffold for Construction of Targeted Anti-cancer Agents". Journal of Advanced Pharmacy Research, 2, 1, 2018, 1-19. doi: 10.21608/aprh.2017.4832
Adel, M., Serya, R., Lasheen, D., Abouzid, K. (2018). 'Pyrrolopyrimidine: A Versatile Scaffold for Construction of Targeted Anti-cancer Agents', Journal of Advanced Pharmacy Research, 2(1), pp. 1-19. doi: 10.21608/aprh.2017.4832
Adel, M., Serya, R., Lasheen, D., Abouzid, K. Pyrrolopyrimidine: A Versatile Scaffold for Construction of Targeted Anti-cancer Agents. Journal of Advanced Pharmacy Research, 2018; 2(1): 1-19. doi: 10.21608/aprh.2017.4832
Pyrrolopyrimidine: A Versatile Scaffold for Construction of Targeted Anti-cancer Agents
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt
Abstract
Pyrrolopyrimidine derivatives comprise a class of biologically active heterocyclic compounds that are well known to play a critical role in pharmaceutical drug design and health care. The pyrrolopyrimidines serve as promising scaffolds that were found in a number of biologically active compounds including antibiotics, anti-inflammatory, anti-viral and anticancer. Researchers were inspired to develop novel pyrrolopyrimidine derivatives for the treatment of Cancer. Currently several pyrrolopyrimidines are available commercially as anticancer drugs.The present review article offers a detailed account on the development of pyrrolopyrimidine derivatives with anticancer potential with emphasis on their activity as targeted kinase inhibitors.
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