Development of a Method for the Determination of Miconazole in Water Samples Using Gas Chromatography Mass Spectrometry

Document Type : Research Article

Authors

1 Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

2 Pharmaceutical of Analytical Chemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt

3 Research Laboratories, Ministry of Health, Giza, Egypt

Abstract

This paper describes an enhanced gas chromatography mass spectrometry (GC-MS) strategy for the analysis of Miconazole in water samples. In this study, determination of Miconazole has been carried out according to standard method for water and waste water analysis. Samples of collected water were agriculture stream water, River Nile water and Hospital waste water samples from El-Gharbia governorate in Egypt. Miconazole was extracted by solid - liquid extraction and analyzed by GC-MS. The chromatographic separation was performed using a ZB5 column (30 m ×0.53 mm, 1.50 µm), and helium as a carrier gas. The limit of detection and limit of quantification for Miconazole were 0.75and 2.50 ng/mL respectively. The intra- and inter-day precisions were lower than 0.85% while the accuracy ranged from 98.55% to 101.53. Finally, solid phase extraction (SPE) in combination with GC-MS is a sensitive and effective method for the determination of Miconazole in water samples.

Keywords

Journal of Advanced Pharmacy Research
Volume 3, Issue 4
October 2019
Pages 194-199

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