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Ibrahim, M., Mohamed, A., Ahmed, A. (2019). Development of a Method for the Determination of Miconazole in Water Samples Using Gas Chromatography Mass Spectrometry. Journal of Advanced Pharmacy Research, 3(4), 194-199. doi: 10.21608/aprh.2019.15686.1089
Mohammed Ibrahim; Ahmed Mohamed; Ahmed Ahmed. "Development of a Method for the Determination of Miconazole in Water Samples Using Gas Chromatography Mass Spectrometry". Journal of Advanced Pharmacy Research, 3, 4, 2019, 194-199. doi: 10.21608/aprh.2019.15686.1089
Ibrahim, M., Mohamed, A., Ahmed, A. (2019). 'Development of a Method for the Determination of Miconazole in Water Samples Using Gas Chromatography Mass Spectrometry', Journal of Advanced Pharmacy Research, 3(4), pp. 194-199. doi: 10.21608/aprh.2019.15686.1089
Ibrahim, M., Mohamed, A., Ahmed, A. Development of a Method for the Determination of Miconazole in Water Samples Using Gas Chromatography Mass Spectrometry. Journal of Advanced Pharmacy Research, 2019; 3(4): 194-199. doi: 10.21608/aprh.2019.15686.1089

Development of a Method for the Determination of Miconazole in Water Samples Using Gas Chromatography Mass Spectrometry

Article 3, Volume 3, Issue 4, October 2019, Page 194-199  XML PDF (323.66 K)
Document Type: Research Article
DOI: 10.21608/aprh.2019.15686.1089
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Authors
Mohammed Ibrahim1; Ahmed Mohamed2; Ahmed Ahmed email 3
1Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
2Pharmaceutical of Analytical Chemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt
3Research Laboratories, Ministry of Health, Giza, Egypt
Abstract
This paper describes an enhanced gas chromatography mass spectrometry (GC-MS) strategy for the analysis of Miconazole in water samples. In this study, determination of Miconazole has been carried out according to standard method for water and waste water analysis. Samples of collected water were agriculture stream water, River Nile water and Hospital waste water samples from El-Gharbia governorate in Egypt. Miconazole was extracted by solid - liquid extraction and analyzed by GC-MS. The chromatographic separation was performed using a ZB5 column (30 m ×0.53 mm, 1.50 µm), and helium as a carrier gas. The limit of detection and limit of quantification for Miconazole were 0.75and 2.50 ng/mL respectively. The intra- and inter-day precisions were lower than 0.85% while the accuracy ranged from 98.55% to 101.53. Finally, solid phase extraction (SPE) in combination with GC-MS is a sensitive and effective method for the determination of Miconazole in water samples.
Keywords
Determination; Gas chromatography Mass Spectrometry; Miconazole; Water samples
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