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Yilmaz, B., Kaban, S. (2018). UV and First Derivative Spectrophotometric Methods for the Estimation of Atorvastatin in Pharmaceutical Preparations. Journal of Advanced Pharmacy Research, 2(2), 89-94. doi: 10.21608/aprh.2018.5824
Bilal Yilmaz; Selcuk Kaban. "UV and First Derivative Spectrophotometric Methods for the Estimation of Atorvastatin in Pharmaceutical Preparations". Journal of Advanced Pharmacy Research, 2, 2, 2018, 89-94. doi: 10.21608/aprh.2018.5824
Yilmaz, B., Kaban, S. (2018). 'UV and First Derivative Spectrophotometric Methods for the Estimation of Atorvastatin in Pharmaceutical Preparations', Journal of Advanced Pharmacy Research, 2(2), pp. 89-94. doi: 10.21608/aprh.2018.5824
Yilmaz, B., Kaban, S. UV and First Derivative Spectrophotometric Methods for the Estimation of Atorvastatin in Pharmaceutical Preparations. Journal of Advanced Pharmacy Research, 2018; 2(2): 89-94. doi: 10.21608/aprh.2018.5824

UV and First Derivative Spectrophotometric Methods for the Estimation of Atorvastatin in Pharmaceutical Preparations

Article 2, Volume 2, Issue 2, April 2018, Page 89-94  XML PDF (388.58 K)
Document Type: Research Article
DOI: 10.21608/aprh.2018.5824
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Authors
Bilal Yilmaz email orcid ; Selcuk Kaban
Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey
Abstract
Objective: In this study, new, rapid UV spectrophotometry (UV) and first-order derivative spectrophotometry (1D) methods were developed for the determination of atorvastatin in pure and tablets. Methods: The solvent system and wavelength of detection were optimized in order to maximize the sensitivity of the proposed methods. Parameters such as linearity, precision, accuracy, specificity, stability, limit of detection and limit ofquantification were studied according to the International Conference on Harmonization Guidelines. Results: Calibration curve was linear between the concentration range of 5-20 μg ml-1. Within- and between-day precision values for atorvastatinwere less than 4.57%, and accuracy (relative error) was better than 3.17%. The mean recovery value of atorvastatinwas 100.1% for pharmaceutical preparations. Conclusion: The developed methods were successfully applied to tablet formulations and the results were compared statistically with each other.
Keywords
Atorvastatin; First-order derivative spectrophotometry; UV spectrophotometry; validation
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