Salama, F., Attia, K., Said, R., El-Olemy, A., Abdel-raoof, A. (2018). Conductometric Titration for Determination of Trazodone Hydrochloride and Solubility Products of its Ion-Associated Complex Species. Journal of Advanced Pharmacy Research, 2(2), 113-122. doi: 10.21608/aprh.2018.5826
Fathy Salama; Khalid Attia; Ragab Said; Ahmed El-Olemy; Ahmed Abdel-raoof. "Conductometric Titration for Determination of Trazodone Hydrochloride and Solubility Products of its Ion-Associated Complex Species". Journal of Advanced Pharmacy Research, 2, 2, 2018, 113-122. doi: 10.21608/aprh.2018.5826
Salama, F., Attia, K., Said, R., El-Olemy, A., Abdel-raoof, A. (2018). 'Conductometric Titration for Determination of Trazodone Hydrochloride and Solubility Products of its Ion-Associated Complex Species', Journal of Advanced Pharmacy Research, 2(2), pp. 113-122. doi: 10.21608/aprh.2018.5826
Salama, F., Attia, K., Said, R., El-Olemy, A., Abdel-raoof, A. Conductometric Titration for Determination of Trazodone Hydrochloride and Solubility Products of its Ion-Associated Complex Species. Journal of Advanced Pharmacy Research, 2018; 2(2): 113-122. doi: 10.21608/aprh.2018.5826
Conductometric Titration for Determination of Trazodone Hydrochloride and Solubility Products of its Ion-Associated Complex Species
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt
Abstract
Objective: Conductometric determination of trazodone hydrochloride, with two precipitating reagents; Ammonium Reineckate and sodium tetraphenylborate has been investigated.Methods: The formed ion-associates were studied conductomterically for the determination of solubility products and other functions associated with the process of precipitating trazodone hydrochloride were determined. Moreover, two new maneuvers towards equivalence point detection were carried out. In this study, data processing was performed using numerical derivatization (second derivative) and Boltzmann algorithm. Results: Although, the described procedures allowed the determination of trazodone hydrochloride within the range of 2-14 mg using both reagents has less sensitivity other than reported method but has more advantages in simplicity, low cost , relatively short analysis time and direct analysis with good recoveries between 100.01% and 100.07% with relative standard deviation less than 2%.Conclusion: These methods were validated and successfully applied for the determination of trazodone hydrochloride in Trittico® tablets. The obtained results were statistically compared with those of the official method by applying t-test and F-value at 95% confidence level and no significant difference was observed regarding accuracy and precision.
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