Home Articles List Article Information
Journal of Advanced Pharmacy Research
Journal Archive
Volume Volume 9 (2025)
Volume Volume 8 (2024)
Volume Volume 7 (2023)
Volume Volume 6 (2022)
Volume Volume 5 (2021)
Volume Volume 4 (2020)
Volume Volume 3 (2019)
Volume Volume 2 (2018)
Volume Volume 1 (2017)
Abdelfattah, A., Elabasawi, N., Attia, K., Abo-serie, A., Morshedy, S. (2018). Densitometric Determination of Ezetimibe in the Presence of its Alkaline Degradation Product. Journal of Advanced Pharmacy Research, 2(3), 212-220. doi: 10.21608/aprh.2018.3242.1053
Ashraf Abdelfattah; Nasr Elabasawi; khalid Attia; Ahmad Abo-serie; Samir Morshedy. "Densitometric Determination of Ezetimibe in the Presence of its Alkaline Degradation Product". Journal of Advanced Pharmacy Research, 2, 3, 2018, 212-220. doi: 10.21608/aprh.2018.3242.1053
Abdelfattah, A., Elabasawi, N., Attia, K., Abo-serie, A., Morshedy, S. (2018). 'Densitometric Determination of Ezetimibe in the Presence of its Alkaline Degradation Product', Journal of Advanced Pharmacy Research, 2(3), pp. 212-220. doi: 10.21608/aprh.2018.3242.1053
Abdelfattah, A., Elabasawi, N., Attia, K., Abo-serie, A., Morshedy, S. Densitometric Determination of Ezetimibe in the Presence of its Alkaline Degradation Product. Journal of Advanced Pharmacy Research, 2018; 2(3): 212-220. doi: 10.21608/aprh.2018.3242.1053

Densitometric Determination of Ezetimibe in the Presence of its Alkaline Degradation Product

Article 7, Volume 2, Issue 3, July 2018, Page 212-220  XML PDF (585.82 K)
Document Type: Short Communication
DOI: 10.21608/aprh.2018.3242.1053
View on SCiNiTO View on SCiNiTO
Authors
Ashraf Abdelfattah email ; Nasr Elabasawi; khalid Attia; Ahmad Abo-serie; Samir Morshedy
Department of Analytical Chemistry, Faculty of Pharmacy, Al Azhar University
Abstract
Objectives: A simple, accurate, selective and sensitive densitometric method was developed for the determination of ezetimibe in the presence of its alkaline degradation product. Methods: TLC-densitometric separation of ezetimibe from its degradation products was carried out on silica gel plates using ethyl acetate: n-hexane (2:1 v/v) as a developing system. This method depends on quantitative densitometric evaluation of ezetimibe at 230 nm over a concentration range of 1–8 µg/spot. Ezetimibe and its alkaline degradation product were resolved with Rf values of 0.49 and 0.68 respectively. Results: The proposed method has been successfully applied to the analysis of ezetimibe in pharmaceutical dosage form without interference from additives and the results were statistically compared with the reported method. Conclusion: TLC- densitometric technique has provided a simple, straightforward method for separating ezetimibe and its alkaline degradation product simultaneously.
Keywords
Alkaline degradation product; Ezetimibe; TLC-densitometry
Statistics
Article View: 371
PDF Download: 809