Salama, F., El abasawy, N., El-Olemy, A., Hasan, M., Kamel, M. (2020). Application of PVC Membrane and Modified Carbon Nanotubes Paste as Electrochemical Sensors for Potentiometric Determination of Loperamide Hydrochloride. Journal of Advanced Pharmacy Research, 4(2), 46-55. doi: 10.21608/aprh.2020.24021.1099
Fathy Salama; Nasr El abasawy; Ahmed El-Olemy; Mohamed Hasan; Mohamed Kamel. "Application of PVC Membrane and Modified Carbon Nanotubes Paste as Electrochemical Sensors for Potentiometric Determination of Loperamide Hydrochloride". Journal of Advanced Pharmacy Research, 4, 2, 2020, 46-55. doi: 10.21608/aprh.2020.24021.1099
Salama, F., El abasawy, N., El-Olemy, A., Hasan, M., Kamel, M. (2020). 'Application of PVC Membrane and Modified Carbon Nanotubes Paste as Electrochemical Sensors for Potentiometric Determination of Loperamide Hydrochloride', Journal of Advanced Pharmacy Research, 4(2), pp. 46-55. doi: 10.21608/aprh.2020.24021.1099
Salama, F., El abasawy, N., El-Olemy, A., Hasan, M., Kamel, M. Application of PVC Membrane and Modified Carbon Nanotubes Paste as Electrochemical Sensors for Potentiometric Determination of Loperamide Hydrochloride. Journal of Advanced Pharmacy Research, 2020; 4(2): 46-55. doi: 10.21608/aprh.2020.24021.1099
Application of PVC Membrane and Modified Carbon Nanotubes Paste as Electrochemical Sensors for Potentiometric Determination of Loperamide Hydrochloride
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.
Abstract
Objectives: The main purpose of this work is to design a simple, sensitive, accurate and precise potentiometric membrane ion selective electrodes for selective determination of loperamide hydrochloride in bulk powder and in pharmaceutical preparation. Methods: Electrochemical behavior of loperamide hydrochloride were investigated using PVC membrane and modified carbon nanotubes paste sensors. The linearity of this developed method was established in the concentration range of 10-5 - 10-2 M and10-6 - 10-2 M shows a Nernstian slope of 57.38 mV and 58.74 mV for PVC and Carbon paste sensor, respectively. Results: Validation parameters such as specificity, linearity, accuracy, precision, stability, limit of detection were found to be within the acceptance limit as studied according to IUPAC recommendation data. Conclusion: Both sensors are successfully applied for potentiometric determination of loperamide hydrochloride in its pure form and pharmaceutical formulations.
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