Antiviral Nucleoside and Nucleotide Analogs: A Review

Mahmoud, Sawsan; Hasabelnaby, Sherifa; Hammad, Sherif; Sakr, Tamer

doi:10.21608/aprh.2018.5829

Antiviral Nucleoside and Nucleotide Analogs: A Review

Document Type : Review Article

Authors

¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo, 11795, Egypt

² Radioactive Isotopes and Generator Department, Hot Labs Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

³ Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University of Modern Sciences and Arts (MSA), Giza, Egypt

10.21608/aprh.2018.5829

Abstract

Virus infections are an increasing and probably lasting global risk. Nucleoside and nucleotide analogs represent the largest class of antiviral drugs. Early success in the treatment of human immunodeficiency virus infection and the recent approval of sofosbuvir as phosphoramidate nucleoside prodrug for chronic hepatitis C have provided proof of concept for important this class of compounds as an antiviral agent. This review summarizes the antiviral activity of nucleoside and nucleotide analogs and their recent application.

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